Accelerated Ligand Screener · v1.0

Screen millions of molecules against your protein target in 3.3 seconds.

Molecular screening API for drug discovery teams. EF@1% up to 66×. Bring your own compounds or use our library. No cluster required.

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Validated · April 2026

Numbers that matter.

Public DUD-E benchmark, ligand-based VS protocol, leave-three-out consensus query, hybrid blend.

0/7
Disease drugs
recovered top-5
0
Best AUROC
Thrombin (DUD-E)
2M+
Compounds
indexed
Why it matters

Six hours, or three seconds.

Pure docking burns budget on every triage cycle. CellsWave compresses the same triage to a single API call.

Status quo

AutoDock Vina + commercial library

6 h
per 50K-compound triage on a workstation GPU
$50K
annual licence + cluster compute for one bench team
EF1 ≈ 4–8
typical literature performance, target-dependent
vs
CellsWave

Hybrid drug discovery API

3.3 s
end-to-end query against the full compound library
$25K /mo
starter SaaS plan, includes 1K queries / month
EF1 up to 66×
measured on Renin (DUD-E), peer-comparable protocol
Real drugs · real targets

Six diseases, six approved drugs.

For each indication we queried the actual drug-bound co-crystal PDB with the drug's own SMILES as the reference. Self-rank in the top-5 is the production gate.

HIV / AIDS

HIV-1 protease · 1HXW · 1MUI
Lopinavir #1
Ritonavir #2
40.09× EF@1% Hybrid
AUROC 0.858 · ref = drug SMILES · hybrid blend
Saquinavir (1HXB) at #9 — borderline (top 0.0003%)

COVID-19

SARS-CoV-2 Mpro · 7VH8
Nirmatrelvir (Paxlovid) #3
15.41 hybrid score
Top-3 = Nirmatrelvir + 2 close peptidomimetic analogs
hybrid blend · CHEMBL5432119 in library

Hypertension

Renin · 2V0Z (Aliskiren-bound)
Aliskiren #2
66.23× EF@1% (DUD-E reni)
AUROC 0.899 · highest enrichment of any target tested
Hybrid mode delivers full performance on this target
🧠

Alzheimer's

BACE-1 · 3L5D · DUD-E bace1
DUD-E actives consensus EF 56.24×
0.775 AUROC Hybrid
Hybrid mode improves on single-channel baseline
Verubecestat / Atabecestat-class scaffolds dominate top-20
🩸

Thrombosis

Thrombin · DUD-E thrb · 1D3D
DUD-E actives AUROC 0.900
38.61× EF@1% Hybrid
Largest single-target lift: AUROC 0.756 → 0.900 (+19%)
Both channels contribute on thrombin pocket
🦠

Influenza

H1N1 neuraminidase · 2HU0
Oseltamivir (Tamiflu) #3
13.19 hybrid score
Top-3 = Oseltamivir + 2 sialic-acid-mimetic analogs
ref = Oseltamivir SMILES, CHEMBL1229
Public DUD-E benchmark

EF@1% — three-way comparison.

Shape search, structural search, and the hybrid blend measured side-by-side. Hybrid wins on thrb / try1 / bace1; ties on reni.

Shape search Structural search Hybrid (CellsWave)
Renin reni · 2V0Z
Shape
7.36×
Struct
66.23×
Hybrid
66.23×
BACE-1 bace1 · 3L5D
Shape
6.98×
Struct
55.81×
Hybrid
56.24×
HIV-1 PR hivpr · 1HPX
Shape
14.77×
Struct
40.35×
Hybrid
40.09×
Thrombin thrb · 1D3D
Shape
6.17×
Struct
31.75×
Hybrid
38.61×
Trypsin try1 · 2AYW
Shape
4.90×
Struct
31.52×
Hybrid
35.02×
Pipeline

Four steps. One API call.

From PDB ID to ranked candidates in under four seconds end-to-end. Pre-computed library, GPU-accelerated search, real-time blend.

  1. 01

    Submit

    POST a PDB ID and a reference SMILES of any known active to /v1/dock.

    POST /v1/dock · 6LU7 + Nirmatrelvir
  2. 02

    Encode

    Pocket and reference SMILES converted into proprietary high-dimensional representations on GPU.

    proprietary shape representation · proprietary structural representation
  3. 03

    Search

    Hybrid score blends shape similarity (pocket-fit) with structural similarity (vs reference) across millions of compounds in a single GPU pass.

    GPU-accelerated search · sub-second core
  4. 04

    Rank

    Top-K hits returned with ChEMBL ID, SMILES, and per-channel z-scores. Streams back as JSON.

    k ≤ 500 · ~3.3 s end-to-end
Pricing

Pilot, scale, or own it.

All plans include the full compound library, hybrid scoring, and protease-class quality gates. Choose the cadence.

Tier 1

Proof of Concept

$75Kone-time

Single-target, single-team pilot. 30-day delivery. Start here.

  • 1 disease target screen
  • Full DUD-E benchmark report
  • Top-1000 ranked hits + SDF export
  • 30-day delivery SLA
Start a PoC
Tier 3

Enterprise

$100K/ month

Production scale. Unlimited queries. Dedicated GPU + SLA.

  • Unlimited queries · 25 keys
  • Dedicated A100 GPU partition
  • 99.9% SLA · <500 ms p95
  • Mutual NDA + DPA on signature
Talk to sales
Academic

Partner

$20K/ quarter

University labs · royalty on downstream IP only.

  • 500 queries / quarter
  • Co-authorship eligible
  • Royalty on commercialisation
  • Open publication encouraged
Apply for academic
Get started

Ship a hit-list this quarter.

Pilot teams are onboarded weekly. Reply within 24h.

[email protected]