MolDyn is a hosted HTTPS API. No GPU, no Docker, no install on your side. All tiers include our validated protease + hydrolase envelope, full DUD-E benchmark access, and DPA + NDA coverage. Start with a Proof of Concept on one of your real targets and convert to a monthly plan once hits are in hand.
| Plan | Price | Why it makes sense |
|---|---|---|
| Proof of Concept | $75,000 one-time | Eight-week scoped engagement on one protease target from your pipeline. Ranked hit list on your target, reproducibility pack, and a structured readout at the end of week 8. Credited 100% against a subsequent monthly plan if you convert within 60 days. The right first step for any team that has not yet benchmarked MolDyn on their real workflow. |
| Starter | $25,000 / month $300,000 / year |
Single active program, up to 3 targets concurrently, up to 50,000 queries / month on the hosted HTTPS API. Fits lean biotech teams running one protease program (HIV, HCV, Mpro, thrombin, BACE1, or a similar validated-class target) that want continuous screening without a multi-year commitment. |
| Professional | $50,000 / month $600,000 / year |
Up to 8 targets concurrently, 250,000 queries / month, priority support (< 4 business hour response), and a dedicated Slack channel with our engineering team. The right fit for biotech teams with a protease-focused portfolio or a CRO running parallel protease programs on client libraries. |
| Enterprise | $100,000 / month $1.2M / year |
Unlimited targets, unlimited queries, dedicated GPU capacity (no shared-queue contention), custom DPA terms, 24 × 7 support SLA, and quarterly roadmap sessions with the engineering lead. For established pharma groups or large CROs treating MolDyn as infrastructure. |
| Partner | $20,000 / quarter + 2–5% royalty |
Low fixed fee plus a milestone-based royalty on any clinical asset that originates from MolDyn-ranked hits. For academic labs, translational groups, and seed-stage biotechs where cash burn matters more than upside-capture. Royalty band is negotiated per program against development stage and exclusivity. |
Representative pricing for a one-year protease-screening engagement at a mid-size biotech. Public pricing / industry norms where known.
| Vendor | Annual cost | Pricing model | Infrastructure on your side | Throughput at 2.6M library |
|---|---|---|---|---|
| MolDyn (Starter) | $300,000 | Flat monthly, hosted API | None | ~200 ms per query |
| MolDyn (Pro) | $600,000 | Flat monthly, hosted API | None | ~200 ms per query |
| Schrödinger Glide SP | ~$400K–$1.2M | Per-seat licensing + hardware | HPC cluster | Hours per 1,000 molecules |
| OpenEye ROCS + FRED | ~$250K–$600K | Seat licensing + compute | Linux cluster | Minutes-hours per 1,000 molecules |
| Chemical Computing MOE | ~$200K–$500K | Seat licensing + compute | Workstation + cluster | Hours per 1,000 molecules |
| CRO screening (Enamine REAL, etc.) | $100K–$5M+ per project | Per-screen bespoke quote | None (but you pay per screen) | Weeks to quote, then compute time |
| AutoDock Vina (open source) | $0 software | Free; you bring infrastructure + team | GPU cluster + headcount | Seconds-minutes per molecule |
All third-party figures are industry estimates based on publicly reported seat pricing and typical deployment cost. Actual enterprise licensing at Schrödinger / OpenEye / CCG varies significantly by team size and contract terms.
For targets not listed above, contact us. We will run a mini-benchmark on your specific target before committing to a paid engagement.
If your program is in an unvalidated class, we continuously improve our envelope. Contact us with your specific target and we’ll tell you honestly whether v1.0 is the right fit today.
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